
ICSN3250 hydrochloride
CAS No. 1561902-79-1
ICSN3250 hydrochloride( ICSN-3250 )
Catalog No. M12224 CAS No. 1561902-79-1
ICSN3250 (ICSN-3250) hydrochloride is a halitulin-analogue that acts as a new-class, specific mTOR inhibitor.
Purity : >98% (HPLC)






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Biological Information
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Product NameICSN3250 hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionICSN3250 (ICSN-3250) hydrochloride is a halitulin-analogue that acts as a new-class, specific mTOR inhibitor.
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DescriptionICSN3250 (ICSN-3250) hydrochloride is a halitulin-analogue that acts as a new-class, specific mTOR inhibitor through a mechanism distinct from previous mTOR inhibitors; ICSN3250 is not a kinase inhibitor of mTOR, competes with and displaces phosphatidic acid from the FRB domain in mTOR, thus preventing mTOR activation and leading to cytotoxicity; displays no inhibitory capacity towards PI3Kα, β, γ, or δ; inhibits mTORC1 by following an unprecedented mechanism that involved its competition with PA at the FRB domain of mTOR to overcome the TSC negative regulation of mTORC1; ICSN3250 specifically targets cancer cells both in vitro and ex vivo.
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In Vitro——
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In Vivo——
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SynonymsICSN-3250
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PathwayPI3K/Akt/mTOR signaling
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TargetmTOR
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RecptormTOR
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Research Area——
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Indication——
Chemical Information
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CAS Number1561902-79-1
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Formula Weight633.139
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Molecular FormulaC31H41ClN4O8
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Purity>98% (HPLC)
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Solubility——
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SMILESC1CCCCCCN(CCCCC1)CCCN2C=C(C(=C2)C3=CC(=C(C(=C3)O)O)[N+](=O)[O-])C4=CC(=C(C(=C4)O)O)[N+](=O)[O-].Cl
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Chemical Name5,5'-(1-(3-(azacyclotridecan-1-yl)propyl)-1H-pyrrole-3,4-diyl)bis(3-nitrobenzene-1,2-diol) hydrochloride
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Nguyen TL, et al. Cancer Res. 2018 Jul 27. pii: canres.0232.2018.
molnova catalog



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